Center for Diabetes and Metabolic Diseases

It is estimated that nearly 10% of the United States population has diabetes, and the percentage with obesity and prediabetes is alarmingly higher.  In response, the IU Center for Diabetes and Metabolic Diseases (CDMD), an NIH funded Diabetes Research Center, was designed to centralize and leverage resources in order to tackle the causes, diagnoses, and treatment of diabetes and related metabolic disorders and their complications across the state.

The Center includes over 60 investigators engaged in basic and translational research in diabetes and related metabolic disorders and houses four research cores that serve as vital resources for innovative and translational research. The research program at the CDMD is augmented by educational and funding activities that cultivate and promote the burgeoning pool of superb investigators with the potential to become future leaders in diabetes research. In addition, the CDMD serves as a dynamic link between researchers, scientific discoveries, and the local community in order to raise diabetes awareness and involvement.

Key Scientific Areas

Members of the CDMD are a distinguished group of NIH, NSF, and major foundation funded researchers with a range of research endeavors that can be classified into five encompassing categories:  Cellular and Molecular Metabolism, Clinical and Outcomes Research, Complications of Diabetes and Obesity, Islet Function and Survival and Nutritional and Physiology of Obesity.

Key Cores

The CDMD supports four state-of-the-art research cores to augment scientific discoveries:  the Islet & Physiology Core, the Microscopy Core, the Swine  Core, and the Translation Core.  

The Islet & Physiology Core provides investigators with the capability to obtain high quality quantitative structural and functional studies of islets and pancreata from rodents, swine, and humans. Islet Core personnel help strategize attainment of complete data sets tailored to the needs of the particular animal/human cell model system.

The Swine Core reduces barriers to the use of Ossabaw swine, a unique animal model that closely approximates human metabolic syndrome (MetS) and progression to type 2 diabetes. Providing this animal resource enables testing of numerous hypotheses about the integrated, in vivo pathogenesis and long-term complications of MetS and type 2 diabetes and provides tissues for studies of cellular and molecular mechanisms. 

The Microscopy Core supports the needs of Center investigators for high-resolution and quantitative optical microscopy, providing training and access to advanced forms of light microscopy and digital image analysis, including intravital microscopy.

The Translation Core provides investigators with in vivo measurements in human subjects or tissues for physiologic, translational and proof-of principle studies in humans. The Translation Core is not only essential for the work of a number of established clinical investigators but is also an important conduit facilitating entry into the field of diabetes research for investigators not traditionally working with human subjects or human subjects materials.

Leadership

External Advisors:

Philipp E. Scherer, PhD:  Distinguished Chair in Diabetes Research, The University of Texas Southwestern Medical Center   

Charles F. Burant, MD, PhD:  Dr. Robert C. and Veronica Atkins Professor of Metabolism, University of Michigan Medical School

Ann Marie Schmidt, MD: Dr. Iven Young Professor of Endocrinology, Department of Medicine Professor, Departments of Biochemistry & Molecular Pharmacology and Pathology, New York University Medical School

Internal Advisors:

Anantha Shekhar, MD, PhD:  Associate Dean for Translational Research, IU School of Medicine   

Richard Di Marchi, PhD:  Linda & Jack Gill Chair in Biomolecular Sciences, Indiana University   

Mark W. Geraci, MD: Chair, Department of Medicine, IU School of Medicine  

Amy Conrad Warner:  Vice Chancellor for Community Engagement, IUPUI  

Executive Committee Members:

Raghu Mirmira, MD, PhD:  Director, CDMD

Robert Considine, PhD:  Associate Director, Basic Research Cores, CDMD

Jeffrey Elmendorf, PhD:  Associate Director, Faculty/Trainee Development, CDMD

Carmella Evans-Molina, MD, PhD:  Associate Director, Center Development, Director, Islet & Physiology Core, CDMD

Kieren Mather, MD:  Associate Director, Clinical Research, Director, Translation Core, CDMD

X. Charlie Dong, PhD:  Executive Committee Member, CDMD

Nuria Morral, PhD:  Co-Director, Enrichment, CDMD

Peter Roach, PhD:  Co-Director, Enrichment, CDMD

Patrick Fueger, PhD:  Executive Committee Member, CDMD

Michael Sturek, PhD:  Director, Swine Core, CDMD

Kenneth W. Dunn, PhD:  Director, Microscopy Core, CDMD

Mary DeGroot, PhD, Executive Committee Member, CDMD  

Lynn Pressler, MBA:  Fiscal Officer, CDMD