January 29, 2020
How Does Exercise Really Increase Muscle Glucose Uptake?
Associate Research Fellow Carol Witczak, one of the newest members of the Indiana Biosciences Research Institute’s (IBRI) Diabetes Center says, “Yes, but the real question is which facilitative glucose transporter...
January 03, 2020
IBRI RESEARCH PUBLISHED: Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
Adult human pancreatic beta cells are the “gold standard” for studies on diabetes pathogenesis, but their use is limited by insufficient availability and variable quality. An important effort has recently...
December 03, 2019
IBRI RESEARCH PUBLISHED: Hypusine biosynthesis in ß cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis
Deoxyhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly defined mechanisms. Because germline deletion of Dhps...
November 21, 2019
IBRI IN THE NEWS: Researchers working to understand why some patients with autoimmune diseases develop diabetes instead of arthritis
Autoimmune diseases are immune system disorders where the body’s immune system attacks its own tissues. Examples of common autoimmune diseases include rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, type...
November 11, 2019
Autoimmune Diseases: Why Diabetes rather than Arthritis?
INDIANAPOLIS, IND. -- Autoimmune diseases such as type 1 diabetes, rheumatoid arthritis, multiple sclerosis etc., are a case of “mistaken identity;” the immune system that is supposed to protect us...
October 08, 2019
Indiana life sciences organizations partner to launch new information source
Seven Indiana life sciences organizations today launched INscience, a one-stop shop for the sector’s news, events, jobs, and other information via a progressive web app on a mobile device. BioCrossroads,...
July 25, 2019
IBRI announces research team for its Diabetes Center
INDIANAPOLIS, IND. – The Indiana Biosciences Research Institute (IBRI) today announced new investigators for the IBRI Diabetes Center (IDC) .
At its first diabetes seminar, held today at Lilly...
June 24, 2019
Interdisciplinary research pushes science in new directions
WEST LAFAYETTE, IND. — A completely new approach to discovering pharmaceutical biologics to fight infectious diseases, new therapies for autism, and exploring a newly discovered intermediate between classical and quantum...
June 20, 2019
IBRI in license agreement for access to Lilly’s Fab Phage Display Library
INDIANAPOLIS, IND. – The Indiana Biosciences Research Institute (IBRI) today announced it has entered into a license agreement with Eli Lilly and Company for the IBRI to access Lilly’s proprietary...
May 28, 2019
Purdue Discovery Park announces Big Idea Challenge 2.0 winners
Following oral presentations on May 7, a panel of judges and Discovery Park administration have reviewed the proposals and determined the winners of the Big Idea Challenge 2.0 , a...
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