March 05, 2020

RESEARCH PUBLISHED: Ventromedial Hypothalamic Nucleus Neuronal Subset Regulates Blood Glucose Independently of Insulin

ABSTRACT To identify neurons that specifically increase blood glucose from among the diversely-functioning cell types in the ventromedial hypothalamic nucleus (VMN), we studied the cholecystokinin (CCK) receptor-B (CCKBR)-expressing VMN...

February 05, 2020

Developing Beta Cell Imaging Probes to Address Type 1 Diabetes Treatment

One of our newest postdoctoral fellows, Stephane Demine , recently shared with the Indiana Biosciences Research Institute (IBRI) team the benefits of using PET-CT scans. The development of such probes...

January 30, 2020

IBRI RESEARCH PUBLISHED: Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia

Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease with a prevalence of 1/30,000 in Whites. Most patients are homozygous for a GAA trinucleotide repeat expansion in the first intron...

January 29, 2020

How Does Exercise Really Increase Muscle Glucose Uptake?

Associate Research Fellow Carol Witczak, one of the newest members of the Indiana Biosciences Research Institute’s (IBRI) Diabetes Center says, “Yes, but the real question is which facilitative glucose transporter...

January 03, 2020

IBRI RESEARCH PUBLISHED: Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

Adult human pancreatic beta cells are the “gold standard” for studies on diabetes pathogenesis, but their use is limited by insufficient availability and variable quality. An important effort has recently...

December 03, 2019

IBRI RESEARCH PUBLISHED: Hypusine biosynthesis in ß cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

Deoxyhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly defined mechanisms. Because germline deletion of Dhps...

November 21, 2019

IBRI IN THE NEWS: Researchers working to understand why some patients with autoimmune diseases develop diabetes instead of arthritis

Autoimmune diseases are immune system disorders where the body’s immune system attacks its own tissues. Examples of common autoimmune diseases include rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, type...

November 11, 2019

Autoimmune Diseases: Why Diabetes rather than Arthritis?

INDIANAPOLIS, IND. -- Autoimmune diseases such as type 1 diabetes, rheumatoid arthritis, multiple sclerosis etc., are a case of “mistaken identity;” the immune system that is supposed to protect us...

October 08, 2019

Indiana life sciences organizations partner to launch new information source

Seven Indiana life sciences organizations today launched INscience, a one-stop shop for the sector’s news, events, jobs, and other information via a progressive web app on a mobile device. BioCrossroads,...

July 25, 2019

IBRI announces research team for its Diabetes Center

INDIANAPOLIS, IND. – The Indiana Biosciences Research Institute (IBRI) today announced new investigators for the IBRI Diabetes Center (IDC) . At its first diabetes seminar, held today at Lilly...

First ... 6 7 8 9 10  ... Last 
2020 Annual Report cover

The IBRI 2020 Annual Report is now available. The report theme, ‘Shaping the Future of Translational Science,’ reflects the IBRI’s commitment to turning scientific discovery into improved outcomes for patients.