5/26/2020

New Research Identifies Two Classes of Drugs that Could be Re-purposed for the Early Treatment of T1D

INDIANAPOLIS - Researchers from the Indiana Biosciences Research Institute (IBRI), a leadi...

5/13/2020

IBRI RESEARCH PUBLISHED: Pancreatic ß-cells in Type 1 and Type 2 Diabetes Mellitus: Different Pathways to Failure

Abstract: Loss of functional β-cell mass is the key mechanism leading to the two main for...

4/16/2020

IBRI IN THE NEWS: IBRI Names Scientific Director

INDIANAPOLIS - The Indiana Biosciences Research Institute has named Investigator Decio Eizirik ...

4/15/2020

IBRI Names Decio Eizirik Scientific Director of its IBRI Diabetes Center

INDIANAPOLIS, IND. – The Indiana Biosciences Research Institute (IBRI) is pleased to announce ...

4/13/2020

IBRI RESEARCH PUBLISHED: The T1D-associated lncRNA Lnc13 modulates human pancreatic ß cell inflammation by allele-specific stabilization of STAT1 mRNA

The mechanisms by which autoimmunity is amplified in type 1 diabetes (T1D) remain to be clarified, a...

3/24/2020

IBRI RESEARCH PUBLISHED: Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes

ABSTRACT The gene encoding eukaryotic initiation factor 5A (EIF5A) is found in diabetes-susceptibil...

3/13/2020

IBRI RESEARCH PUBLISHED: Utilization of Electronic Health Records for the Assessment of Adiponectin Receptor Autoantibodies during the Progression of Cardio-metabolic Comorbidities

ABSTRACT Background: Diabetes is a complex, multi-symptomatic disease that drives healthcare costs ...

3/5/2020

RESEARCH PUBLISHED: Ventromedial Hypothalamic Nucleus Neuronal Subset Regulates Blood Glucose Independently of Insulin

ABSTRACT To identify neurons that specifically increase blood glucose from among the diversely-func...

2/5/2020

Developing Beta Cell Imaging Probes to Address Type 1 Diabetes Treatment

One of our newest postdoctoral fellows, Stephane Demine, recently shared with the Indiana Biosc...

1/30/2020

IBRI RESEARCH PUBLISHED: Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia

Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease with a prevalence of 1/...

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2019 Annual Report cover

The IBRI 2019 Annual Report is now available. The report theme is “Catalyze, Complement, Connect,” which correlates with the IBRI's goals to seek solutions for health problems, enhance the Indiana life sciences ecosystem, and expedite solutions for the most pressing health issues.