4/13/2020

IBRI RESEARCH PUBLISHED: The T1D-associated lncRNA Lnc13 modulates human pancreatic ß cell inflammation by allele-specific stabilization of STAT1 mRNA

The mechanisms by which autoimmunity is amplified in type 1 diabetes (T1D) remain to be clarified, a...

3/24/2020

IBRI RESEARCH PUBLISHED: Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes

ABSTRACT The gene encoding eukaryotic initiation factor 5A (EIF5A) is found in diabetes-susceptibil...

3/13/2020

IBRI RESEARCH PUBLISHED: Utilization of Electronic Health Records for the Assessment of Adiponectin Receptor Autoantibodies during the Progression of Cardio-metabolic Comorbidities

ABSTRACT Background: Diabetes is a complex, multi-symptomatic disease that drives healthcare costs ...

3/5/2020

RESEARCH PUBLISHED: Ventromedial Hypothalamic Nucleus Neuronal Subset Regulates Blood Glucose Independently of Insulin

ABSTRACT To identify neurons that specifically increase blood glucose from among the diversely-func...

2/5/2020

Developing Beta Cell Imaging Probes to Address Type 1 Diabetes Treatment

One of our newest postdoctoral fellows, Stephane Demine, recently shared with the Indiana Biosc...

1/30/2020

IBRI RESEARCH PUBLISHED: Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia

Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease with a prevalence of 1/...

1/29/2020

How Does Exercise Really Increase Muscle Glucose Uptake?

Associate Research Fellow Carol Witczak, one of the newest members of the Indiana Biosciences R...

1/3/2020

IBRI RESEARCH PUBLISHED: Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

Adult human pancreatic beta cells are the “gold standard” for studies on diabetes pathog...

12/3/2019

IBRI RESEARCH PUBLISHED: Hypusine biosynthesis in ß cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

Deoxyhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modification of...

11/21/2019

IBRI IN THE NEWS: Researchers working to understand why some patients with autoimmune diseases develop diabetes instead of arthritis

Autoimmune diseases are immune system disorders where the body’s immune system attacks its own...

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2019 Annual Report cover

The IBRI 2019 Annual Report is now available. The report theme is “Catalyze, Complement, Connect,” which correlates with the IBRI's goals to seek solutions for health problems, enhance the Indiana life sciences ecosystem, and expedite solutions for the most pressing health issues.