Research Summary

IBRI DIABETES CENTER (IDC) - TEMPLIN LAB

Focus: Investigating the cellular mechanism that underlie the relationship between islet immune responses and beta cell death in diabetes.

The immune system is known to play a critical role in the pathogenesis of type 1 diabetes, and an increasing body of evidence now suggests it plays an important role in type 2 diabetes as well. The Templin Lab is focused on investigating the relationship between islet immune responses and beta cell dysfunction and death in the setting of both major forms of diabetes. An emphasis is placed on the concept that beta cell intrinsic properties are central drivers of islet inflammation and immune responses, and together these promote a system of beta cell dysfunction and loss that lead to diabetes.

The Templin Lab works with in vivo mouse models of islet inflammation, diabetes and obesity to assess islet morphologic and whole-body metabolic changes that occur in the animal models under investigation, as well as in vitro studies to examine novel immune-related beta cell death signaling pathways.

Lab Team

Andrew Templin, PhD

Assistant Investigator, IBRI Diabetes Center

Assistant Professor of Medicine, Division of Endocrinology, Indiana University School of Medicine

Postdoctoral Fellow 2018 University of Washington

PhD 2014 Indiana University | BSc 2006 Indiana University

Read ANDREW's Bio

Christopher Contreras, PhD

Christopher Contreras, PhD

Postdoctoral Fellow, IBRI Diabetes Center

Christopher Contreras, PhD

Christopher Contreras, PhD

Postdoctoral Fellow, IBRI Diabetes Center

Christopher Contreras joined the Indiana Biosciences Research Institute (IBRI) in September 2020 as a postdoctoral fellow in the IBRI Diabetes Center’s Templin Lab.

Prior to working at the IBRI, Contreras was a postdocoral fellow at Indiana University School of Medicine in the Herman B Wells Center for Pediatric Research. There, he was investigating the role extracellular vesicles play in beta cell signaling, mechanisms involved with extracellular vesicle cargo loading, as well as the potential for extracellular vesicles as biomarkers for diabetes.

Contreras received his PhD. in biochemistry and molecular biology in 2018 from Indiana University, where he researched abnormalities in glycogen metabolism in Lafora disease. In 2008 he received his bachelors degree in biochemistry and molecular biology from the University of New Mexico.

Additionally, Contreras enjoys mountain biking, fishing and camping.

Li Lin

Li Lin

Assistant Research Associate, IBRI Diabetes Center

Li Lin

Li Lin

Assistant Research Associate, IBRI Diabetes Center

Li Lin joined the IBRI in September 2020 as an assistant research associate in the IBRI Diabetes Center. In this role, she works with Dr. Andrew Templin on the mechanisms of diabetes pathogenesis related to islet immune responses and beta cell death.

Before joining the IBRI, Li worked as a research technician at University of Pittsburgh, where she was involved with lab operations and studies investigating antifungal immune response in the kidney. She also was responsible for animal colony breeding, maintenance and genotyping.

Li received her B.S. in Nursing from Wuhan University in China in 2016 and then earned her Master of Public Health degree in Infectious Diseases and Microbiology from the University of Pittsburgh in 2018.

Andrew Templin, PhD

Andrew Templin, PhD

Assistant Investigator, IBRI Diabetes Center

Andrew Templin, PhD

Andrew Templin, PhD

Assistant Investigator, IBRI Diabetes Center

Andrew Templin joined the IBRI Diabetes Center in June 2020. He also holds positions at the Indiana University (IU) School of Medicine and the Roudebush VA Medical Center. Andrew’s lab studies the relationship between islet inflammation and beta cell dysfunction and death in the setting of diabetes. Ultimately, the goal of the Templin Lab is to uncover novel mechanisms of diabetes pathogenesis that affect islet beta cell health, and to use this information to develop new treatments for diabetes.

Prior to joining the IBRI, Andrew served as an Acting Instructor of Medicine at the University of Washington in Seattle. During his time there, he studied the role of islet amyloidosis in islet inflammation and beta cell loss in collaboration with Dr. Steven Kahn. This collaboration led to publications in Diabetes, Diabetologia, and Diabetes Care, among others.

Andrew received his Bachelor of Science degree from IU in 2006, during which time he was a member of the Hutton Honors College. After working and studying at Northwestern University in the Feinberg School of Medicine, Andrew returned to IU and obtained his PhD in Cellular and Integrative Physiology under the mentorship of Dr. Raghu Mirmira, graduating in 2014.

Andrew is a native Hoosier who enjoys travel, soccer, the Chicago Cubs and Golden Retrievers.