Entrepreneur Expansion

Entrepreneurial Ecosystem Expansion

The Indiana Biosciences Research Institute (IBRI) is proud to promote innovative science. In 2022, the IBRI welcomed four life sciences start-ups, two of which are highlighted below, to work in its space and use its equipment. The IBRI supports entrepreneurship in the life sciences, convenes diverse research teams and complements innovation in the ecosystem. The number of IBRI resident start-ups now totals 13 that are working to create hope for patients through science.

Human papillomavirus infection (stained in brown) in the upper epithelium of the skin
Human papillomavirus infection (stained in brown) in the upper epithelium of the skin.

Treating HPV-related premalignant infections and cancers

Kovina Therapeutics is focused on two objectives - stop Human papillomavirus (HPV) premalignant infections before cancer develops and treat HPV cancers after detection.

Kovina CEO Kristin Sherman and Vice President of Finance Colleen Beeler are dedicated to this work in part due to the potential impact on women’s health. Today, women diagnosed with premalignant cervical infections caused by HPV undergo surgery to treat the infection, which may result in side effects and impact fertility.

“We believe Kovina’s research will lead to a topical medication to treat HPV premalignant infections before cancer forms,” Sherman said. “Kovina also is developing an oral therapeutic for use after HPV progresses and cancer is diagnosed, to provide much-needed treatment options for patients.”

Kovina moved its operations to the IBRI in June 2022. Beeler noted the benefits the IBRI offers the start-up life science community, “In a previous start-up, Kristin and I needed to create a new lab facility for the company but found very few options available. Ultimately, establishing a standalone lab was the best option, which is certainly capital-intensive. The fact that the IBRI offers shared equipment, and the necessary support structure provides a significant benefit for local life science start-ups.”

Alec Brewer and Kobe Rogers, co-founders of Ourobio
Alec Brewer and Kobe Rogers, co-founders of Ourobio.

Moving from Charlottesville to Indianapolis

In 2022, the IBRI was pleased to welcome Ourobio to its Indianapolis, Ind., labs from Charlottesville, Vir. Co-founder Alec Brewer said, “Moving to the IBRI has enabled us to start expanding our team, allowed us to accelerate our progress in developing engineered microorganisms, and provided us with access to higher throughput fermentation equipment we haven’t been able to use since moving out of our university lab.”

This pre-revenue company started as an academic research project called Transfoam in early 2019 and was spun out into a company in March 2020, and rebranded to Ourobio in 2022. The company’s goal is to reduce the creation of microplastic pollution and the barriers to biodegradable plastic adoption.

Co-founders Brewer and Kobe Rogers met in a synthetic biology class at the University of Virginia, where the team bonded over their shared passion for sustainability, synthetic biology and biochemistry. “I’ve witnessed the beauty of the ocean, but also how it’s being treated,” said Rogers. “I realized I could use my knowledge and passion to make a big change in the world.”

This past year, in addition to moving to Indianapolis, Ourobio has conducted a significant amount of market research that showed they have an opportunity to solve an unmet need in the biomaterials/plastics industry. Brewer notes that, “Outreach and interacting with the biomaterials/plastics industry has been our mission since day one. We strive to best meet the needs of consumer-packaged goods manufacturers and consumers.”

Advance Research

2022 Annual Report