Technologies complete in record time
In 2016, when the Single Cell Analytics Center was organized, its mission was to develop technologies that would diagnose diseases efficiently, quickly and accurately. The center set a goal to accomplish this in five years, which at that point was ambitious.
Fast forward to 2019: The center achieved its goal two years ahead of schedule. Under the leadership of Director Michael Pugia, PhD, the center completed BioMEMs and SIERRA.
SIERRA is the Signal Ion Emission Reactive Release Amplification platform that helps diagnose infections and other diseases from a single cell. The research to show SIERRA’s effectiveness for identifying rare cells in whole blood was published in Analytical Chemistry by team members Zane Baird, PhD, and Zehui Cao, PhD, with assistance from Anna Geisinger.
This project also had support from Indiana University-Purdue University Indianapolis, Indiana University School of Medicine and the State of Indiana.
BioMEMs Point of Care (POC) analyzer
BioMEMs is a biological microelectromechanical system that uses micro-sized components to reduce cost and improve sensitivity of diagnostic tests. For this project, we collaborated with Steven Wereley, PhD, at Purdue University and submitted research to Lab on a Chip about this new POC system. We also partnered with Frédérique T. Deiss, PhD, at Indiana University-Purdue University Indianapolis to submit an electrochemistry paper to Analytical Chemistry that demonstrated culture-free bacterial detection in clinical samples.
Now that SIERRA and BioMEMs are complete, we evolved the Single Cell Analytics Center into the Bioanalytical Technologies group that is still being led by Pugia and his team that includes Geisinger and Dylan Frabutt, PhD.