Flak Lab

Research Focus

The CNS control of individual aspects of energy balance and glucose homeostasis.

What We Do

It is well understood that the brain can control energy balance via descending connections (i.e., sympathetic nervous system) with peripheral organs (e.g., pancreas, heart, liver, adrenal). However, the details of these brain systems have not yet been established.

While therapies exist that can successfully target the sympathetic nervous system to restore normal function in obese and diabetic patients, these tools also produce deleterious effects on unwanted and unrelated processes (e.g., cardiovascular disease, renal failure). Thus, the upstream neural system that can specifically target, for example, glucose mobilization, represents the ideal target to curb medical issues associated with complications such as hypoglycemia. Yet, there is only a superficial understanding of the unique cellular components contained within the neural circuits that control these processes.

The Flak Lab is investigating how the brain can separately initiate glucose mobilization and glucose uptake when necessary, with the help of the ADA Pathway Program. The Flak Lab’s goal is to identify ways to target these circuits to promote glucose mobilization during hypoglycemia or curb diabetic hyperglycemia.

In addition to the control of glucose, many overlapping components in these brain areas that influence glucose homeostasis also can influence energy expenditure. Concurrently, the Flak Lab also aims to understand the circuits in the brain that separately control energy expenditure, especially those circuits that can be promoted during periods of exercise and suppressed during fasting and diet conditions.

Using mouse models, the Flak Lab is working to identify the neural circuits, as well as the essential components within these circuits, that are responsible for generating these responses. These studies may reveal new targets for the treatment of obesity and diabetes.

Within the last few years, the Flak Lab has revealed brainstem→hypothalamus circuits that can mobilize blood glucose during periods of hypoglycemia and pain/inflammation, leading to publications in Nature Neuroscience and the Journal of Clinical Investigation.

The Flak Lab is working to establish the downstream connections from the hypothalamus to reveal new targets and strategies to communicate with peripheral organs in order to generate the mobilization of blood glucose, glucose uptake and facilitate energy expenditure.

Jonathan Flak lab team including four scientists

Jonathan Flak, PhD

Jonathan Flak, PhD

Assistant Investigator

  • Postdoctoral Fellow, University of Michigan, 2016
  • Doctor of Philosophy, University of Cincinnati, 2011
  • Bachelor of Science, University of Michigan, 2004

Collaborators

Scientists interested in working in the Flak Lab or collaborating on research should contact Jonathan Flak.

  • Eli Lilly and Company Logo Eli Lilly and Company
  • Indiana University School of Medicine logo Indiana University School of Medicine
  • University of Michigan logo University of Michigan

Lab Positions

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