Scientific Areas

Shaping the Future of Translational Science

Kalwat Lab scientists working
Glass bottles on shelf in lab

The work of the Indiana Biosciences Research Institute (IBRI) reflects the dynamic and evolving role of innovators in the biomedical field and uniquely positions us alongside industry and academia to advance science and drug discovery, and deliver meaningful outcomes for patients.

Science is advancing at a rapid pace. Unprecedented access to novel genetic and genomic analyses of disease tissues along with human-derived models for preclinical experimental work are helping us create powerful discoveries to defeat disease.

These approaches have led to a better molecular understanding of disease and patient heterogeneity, in addition to new therapeutic hypotheses to explore. It is ultimately our goal to return these findings to patients in the form of novel therapies and diagnostics that give patients hope for a brighter future.

We therefore envision translational science as a cyclical process of continual learning, applied research and drug discovery that begins and ends with the patient. Through the lens of a research institute, there are multiple entry points from diverse scientific disciplines for insights, hypothesis generation and medical innovation leading to potential breakthroughs.

The four foundational areas of scientific focus at the IBRI will provide us the core talent and capability to pursue translational science and drug discovery in this new patient-centric framework.

IBRI Partners

Diabetes Research

1 in 10 adults around the world are living with diabetes

IBRI Diabetes Center

"We are using CRISPR screening to identify new drug therapies that can halt type 1 diabetes progression."

Erica Cai, PhD
Cai Lab

iPSC Lab

Indianapolis' first dedicated iPSC lab

Leveraging the iPSC Lab to better understand the pathogenesis of type 1 diabetes by generating human beta cells and neurons.