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IBRI 2021 Annual Report “Accelerating Biomedical Innovation”

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iPSC Lab

Research Focus

Leveraging the iPSC Lab to better understand the pathogenesis of type 1 diabetes by generating human beta cells and neurons.

The stem cells we work with in the Induced Pluripotent Stem Cell (iPSC) Lab, Indianapolis' first dedicated iPSC lab, are adult cells that are modified and derived from human skin or blood cells and then reprogrammed into other human cells. 

The iPSCs we generate can synthesize and secrete insulin and be used to screen for new drugs that may protect beta cells early in the disease and therefore slow the progression of diabetes.

We also can complete CRISPR-Cas9 and pharmacologic screening of iPSC cells. The capabilities of the iPSC Lab allow us to work with researchers around the world—and right here at home—to better understand human disease and identify novel treatments for conditions ranging from diabetes to pediatric cancers.

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Scientists in the iPSC Lab

Collaborators

Scientists interested in working in the iPSC Lab or collaborating on research should contact Jay McGill.

  • Eli Lilly and Company Logo Eli Lilly and Company
  • Indiana University School of Medicine logo Indiana University School of Medicine

Lab Positions

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