March 29, 2021
IBRI RESEARCH PUBLISHED: Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells
Abstract
Background: Type 1 diabetes (T1D) is an autoimmune disease characterized by the progressive destruction of pancreatic beta cells. Interferon-α (IFNα), an antiviral cytokine, is expressed in the pancreatic...
March 19, 2021
IBRI IN THE NEWS: IBRI's new CEO brings experience from industry, academia
Dr. Alan Palkowitz spent 28 years in industry before becoming an academic research scientist. Those two experiences were perfect preparation for his new role as the leader of an organization...
February 19, 2021
IBRI RESEARCH PUBLISHED: Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis
Abstract
The presence of islet cells double positive for insulin and glucagon (Ins + /Glu + ) has been described in the pancreas from both type 2 (T2D) and...
January 28, 2021
IBRI IN THE NEWS: IBRI Researchers Find Opportunity to Repurpose Drugs for Type 1 Diabetes
More than 7% of Americans suffer from debilitating and, in some cases, life-threatening autoimmune diseases. With diagnoses on the rise, researchers continue the quest for more effective treatments and the...
January 07, 2021
IBRI RESEARCH PUBLISHED: Gene Expression Signatures of Target Tissues in Type 1 Diabetes, Lupus Erythematosus, Multiple Sclerosis, and Rheumatoid Arthritis
Abstract
Autoimmune diseases are typically studied with a focus on the immune system, and less attention is paid to responses of target tissues exposed to the immune assault. We...
January 06, 2021
A New Approach to Study Autoimmune Diseases
Indianapolis, Ind. - A team of researchers led by the Indiana Biosciences Research Institute Diabetes Center’s Scientific Director Decio L. Eizirik, MD, PhD, has found that identifying new treatments for...
December 29, 2020
IBRI RESEARCH PUBLISHED: The RNA-binding Profile of the Splicing Factor SRSF6 in Immortalized Human Pancreatic ß-cells
Abstract
In pancreatic β-cells, the expression of the splicing factor SRSF6 is regulated by GLIS3, a transcription factor encoded by a diabetes susceptibility gene. SRSF6 down-regulation promotes β-cell demise...
December 01, 2020
IBRI RESEARCH PUBLISHED: Persistent or Transient Human ß Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes
Abstract
Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whether human β cell dysfunction induced by metabolic stress is reversible,...
November 28, 2020
IBRI RESEARCH PUBLISHED: Phenotypic Sexual Dimorphism in Response to Dietary Fat Manipulation in C57BL/6J Mice
Abstract
Background : Obesity and the metabolic syndrome are increasingly prevalent in society and their complications and response to treatment exhibit sexual dimorphism. Mouse models of high fat diet-induced...
November 20, 2020
IBRI RESEARCH PUBLISHED: Integration of single-cell datasets reveals novel transcriptomic signatures of ß-cells in human T2D
Abstract
Pancreatic islet β-cell failure is key to the onset and progression of type 2 diabetes (T2D). The advent of single-cell RNA sequencing (scRNA-seq) has opened the possibility to...
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