IBRI RESEARCH PUBLISHED: The T1D-associated lncRNA Lnc13 modulates human pancreatic ß cell inflammation by allele-specific stabilization of STAT1 mRNA
The mechanisms by which autoimmunity is amplified in type 1 diabetes (T1D) remain to be clarified, and the lack of this understanding hampers efforts to prevent or arrest the disease....
IBRI RESEARCH PUBLISHED: Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes
ABSTRACT The gene encoding eukaryotic initiation factor 5A ( EIF5A ) is found in diabetes-susceptibility loci in mouse and human. eIF5A is the only protein known to contain hypusine...
Utilization of Electronic Health Records for the Assessment of Adiponectin Receptor Autoantibodies during the Progression of Cardio-metabolic Comorbidities
ABSTRACT Background : Diabetes is a complex, multi-symptomatic disease that drives healthcare costs through its complications as the prevalence of this disease grows rapidly world-wide. Real-world electronic health records...
RESEARCH PUBLISHED: Ventromedial Hypothalamic Nucleus Neuronal Subset Regulates Blood Glucose Independently of Insulin
ABSTRACT To identify neurons that specifically increase blood glucose from among the diversely-functioning cell types in the ventromedial hypothalamic nucleus (VMN), we studied the cholecystokinin (CCK) receptor-B (CCKBR)-expressing VMN...
Developing Beta Cell Imaging Probes to Address Type 1 Diabetes Treatment
One of our newest postdoctoral fellows, Stephane Demine, recently shared with the Indiana Biosciences Research Institute (IBRI) team the benefits of using PET-CT scans. The development of such probes is...
IBRI RESEARCH PUBLISHED: Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia
Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease with a prevalence of 1/30,000 in Whites. Most patients are homozygous for a GAA trinucleotide repeat expansion in the first intron...
How Does Exercise Really Increase Muscle Glucose Uptake?
Associate Research Fellow Carol Witczak, one of the newest members of the Indiana Biosciences Research Institute’s (IBRI) Diabetes Center says, “Yes, but the real question is which facilitative glucose transporter...
IBRI RESEARCH PUBLISHED: Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
Adult human pancreatic beta cells are the “gold standard” for studies on diabetes pathogenesis, but their use is limited by insufficient availability and variable quality. An important effort has recently...
IBRI RESEARCH PUBLISHED: Hypusine biosynthesis in ß cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis
Deoxyhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly defined mechanisms. Because germline deletion of Dhps...
IBRI IN THE NEWS: Researchers working to understand why some patients with autoimmune diseases develop diabetes instead of arthritis
Autoimmune diseases are immune system disorders where the body’s immune system attacks its own tissues. Examples of common autoimmune diseases include rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, type...