Michael Kalwat, PhD, investigates the molecular mechanisms of regulated secretion and the use of genetic and pharmacological tools for this purpose. Kalwat also is a member of the Indiana University School of Medicine Center for Diabetes and Metabolic Diseases.
The Kalwat Lab will bridge small molecule and genetic high-throughput screening with target and pathway identification in dedicated secretory cell types. Because many of these cell types malfunction in metabolic diseases (i.e., failure of insulin-secreting β cells in diabetes), new knowledge about the regulation of their basic cell biological functions is critical to advancing the field and therapeutic development.
Prior to joining the Indiana Biosciences Research Institute, Kalwat trained as a postdoctoral researcher in the lab of Melanie Cobb at the University of Texas Southwestern Medical Center, where he developed key reagents for assaying secretory cell function. His work yielded a cohort of distinct small molecule secretion modulators with impacts on calcium influx, cAMP generation and the unfolded protein response.
Subsequently, he completed his PhD dissertation in Debbie Thurmond’s lab in the Department of Biochemistry and Molecular Biology at Indiana University School of Medicine in 2012, where he focused on cytoskeletal regulation of exocytosis.
View Kalwat's published research here.