Roberto Mallone, MD, PhD

Senior Investigator

Joined the IBRI in April 2023

Roberto Mallone

Roberto Mallone, MD, PhD, and his colleague Sylvaine You, PhD, launched a satellite lab at the Indiana Biosciences Research Institute (IBRI) in 2023 that is focused on exploring autoimmune T cells and understanding type 1 diabetes (T1D) mechanisms to develop T-cell-based biomarkers and therapeutics.

After he completed a postdoctoral fellowship with Gerald Nepom, MD, PhD, at the Benaroya Research Institute in Seattle, he moved to Paris, where he is currently a professor of clinical immunology at Paris Cité University, a diabetologist at the Cochin Hospital and leader of a research team at the INSERM Cochin Institute.

His major contributions to the field include the isolation of islet-reactive CD4+ and CD8+ T cells from the blood of T1D patients, the demonstration of the central role of CD8+ T cells in beta-cell autoimmunity, the development of T-cell monitoring tools to clarify therapeutic mechanisms in clinical trials, and the exploration of perinatal vaccination strategies to improve thymic immune tolerance mechanisms.

More recently, he described a universal state of ‘benign’ islet autoimmunity imprinted in the thymus (“Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors,” Science Immunology, 2018) and the first immunopeptidome of human beta cells (“Conventional and neo-antigenic peptides presented by beta cells are targeted by circulating naïve CD8+ T cells in type 1 diabetic and healthy donors,” Cell Metabolism, 2018).

Areas of Expertise

  • Antigen identification
  • Autoimmunity
  • Immune tolerance
  • T-cell biology
  • Tolerogenic immunotherapies
  • Type 1 diabetes


  • Doctor of Philosophy (Medical Pathophysiology), University of Turin, 2007
  • Doctor of Medicine (Internal Medicine), University of Turin, 2004

Awards & Certifications

  • The Helmsley Charitable Trust George S. Eisenbarth nPOD Award for Team Science, 2017
  • Auguste Loubatieres Prize of the Societe Francophone du Diabete, 2016
  • Apollinaire Bouchardat Prize, 2012
  • Morgagni Young Investigator Award, 2012
  • Avenir Investigator, 2009
  • Rising Star Award of the European Association for the Study of Diabetes, 2008
  • French National Medical Board, 2008
  • Italian National Medical Board, 2000

Honorary Societies

  • European Association for the Study of Diabetes
  • Immunology of Diabetes Society