Sylvaine You, PhD

Associate Investigator

Joined the IBRI in April 2023

Sylvaine You

Sylvaine You, PhD, and her colleague Roberto Mallone, MD, PhD, launched a satellite lab at the Indiana Biosciences Research Institute (IBRI) in 2023 that is focused on exploring autoimmune T cells and understanding type 1 diabetes (T1D) mechanisms to develop T-cell-based biomarkers and therapeutics.

After a post-doctoral training in the laboratory of Chih-Pin Liu, PhD (City of Hope Medical Center, Beckman Research Institute, Department of Immunology, California), she joined the team of Lucienne Chatenoud at the Necker Hospital in Paris, France, and obtained a permanent position at the National Institute of Health and Medical Research (INSERM) in 2007. Currently, she is a research director and associate professor at the Cochin Institute in Paris, where she co-leads a team with Mallone on T1D immunology.

Her expertise concentrates on T1D pathogenesis and on the pathogenic and regulatory mechanisms that respectively promote or control autoreactive T cells in human and mouse models. Her research interest also focuses on immune strategies to promote and/or restore tolerance using biological agents (CD3 monoclonal antibodies, low-dose IL-2, CD28 antagonist, Fc-fused preproinsulin), with some that have been applied in T1D clinical trials with promising results.

Areas of Expertise

  • Autoimmunity
  • Immune tolerance
  • Immunoregulation
  • Immunotherapies
  • Islet transplantation
  • Mouse models
  • T cells
  • Type 1 diabetes


  • Doctor of Philosophy (Immunology), University of Nantes, France, 2000
  • Master of Science (Immunology), University of Nantes, France, 1996
  • Bachelor of Science (Cell Biology), University of Nantes, France, 1994

Awards & Certifications

  • INSERM Young Investigator Award (2004 to 2006)

Honorary Societies

  • European Association for the Study of Diabetes
  • French Society of Immunology
  • Immunology of Diabetes Society