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IBRI Science Frontiers
3rd Annual Seminar Series

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Mechanisms Mediating Anti-diabetic Actions Fibroblast Growth Factor Signaling in the Brain

Mechanisms Mediating Anti-diabetic Actions Fibroblast Growth Factor Signaling in the Brain

Wednesday, July 20, 2022
11:00 AM - 12:00 PM

Presenter: Jarrad Scarlett, MD, PhD

Organization: University of Washington Medicine, Seattle, Washington

Dr. Jarrad Scarlett is the assistant professor of pediatrics in the division of gastroenterology and hepatology at the University of Washington Medicine.

After completing his undergraduate training at the University of Washington and earning bachelor's degrees in both neurobiology and biochemistry, Dr. Scarlett was accepted into the Medical Scientist Training Program at Oregon Health & Sciences University (OHSU) where he obtained both a PhD in neuroscience and his MD.

He then went on to complete his residency training in pediatrics at OHSU in 2012 and his fellowship training in pediatric gastroenterology, hepatology and nutrition at Seattle Children’s Hospital in 2015. Dr. Scarlett was promoted to assistant professor in 2017.

Dr. Scarlett's recent work in the field of diabetes research supports the concept of a brain-centered glucoregulatory system that works cooperatively with pancreatic islets to regulate blood glucose.

His post-doctoral work identified that the brain is a target for the fibroblast growth factor, FGF1, and that in response to central FGF1 administration that the brain can promote sustained glucose lowering in murine models of obesity and diabetes.

Current studies are focused on elucidating the specific central neurocircuits and signaling pathways that are targeted by central FGF1 therapy and the peripheral mechanisms that are responsible for promoting remission of diabetic hyperglycemia.

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