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IBRI 2021 Annual Report “Accelerating Biomedical Innovation”

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Kalwat Lab

Research Focus

Using genetically-encoded biosensors to gain beta cell knowledge

What We Do

The Kalwat Lab is investigating the molecular mechanisms underlying pancreatic islet beta cell function in health and in type 1 and type 2 diabetes. Beta cells are the sole source of the hormone insulin, which controls glucose homeostasis and these cells are either destroyed or fail to function in diabetes.

Kalwat’s team uses a combination of approaches including small molecule and genetic high-throughput screening, as well as genetically-encoded biosensors to gain knowledge about beta cell function. Identifying new pathways and targets is necessary to develop therapeutics that protect and restore the function of these cells in diabetes.

Kalwat Lab team

Michael Kalwat

Michael Kalwat, PhD

Assistant Investigator

  • Postdoctoral Training, University of Texas Southwestern Medical Center, 2018
  • Doctorate, biochemistry and molecular biology, Indiana University, 2012
  • Bachelor of Science, biochemistry, Purdue University, 2007

Collaborators

Scientists interested in working in the Kalwat Lab or collaborating on research should contact Michael Kalwat.

  • Indiana University logo Indiana University School of Medicine
  • University of Chicago Logo University of Chicago (Mirmira Lab)
  • University of Texas Southwestern Medical Center logo University of Texas Southwestern Medical Center