Templin Lab

Research Focus

Investigating the cellular mechanisms that underlie the relationship between islet immune responses and beta cell death in diabetes.

What We Do

The immune system is known to play a critical role in the pathogenesis of type 1 diabetes, and an increasing body of evidence suggests it plays a role in type 2 diabetes, as well.

Research in the Templin Lab focuses on understanding the relationship between islet immune responses and beta cell dysfunction and death in the setting of both major forms of diabetes. Emphasis is placed on the concept that beta cell intrinsic properties are drivers of islet inflammation and immune responses, and together these promote a system of beta cell dysfunction and loss that lead to diabetes.

The Templin Lab investigates underappreciated mechanisms of inflammatory, lytic beta cell death and whether such forms of death can drive islet inflammation and further promote beta cell loss in diabetes. The Templin Lab also interrogates molecular mechanisms that underlie amyloid-induced islet inflammation and beta cell loss in type 2 diabetes.

These lines of research utilize in vitro models of beta cell death and in vivo models of islet amyloid formation, islet inflammation and beta cell loss to examine whether beta cells themselves promote islet inflammation in diabetes. Through this work, the Templin Lab aims to advance our understanding of beta cell loss in diabetes and, ultimately, improve the health of individuals afflicted with this disease.

Andrew Templin, PhD

Andrew Templin, PhD

Assistant Investigator

  • Assistant Professor, Indiana University School of Medicine
  • Research Scientist, Roudebush VA Medical Center
  • Postdoctoral Fellowship (Islet Biology), University of Washington, 2018
  • Doctor of Philosophy (Cellular and Integrative Physiology), Indiana University, 2014
  • Bachelor of Science (Biology, Chemistry, Business), Indiana University, 2006

Collaborators

Scientists interested in collaborating with the Templin Lab on research should contact Andrew Templin.

  • Indiana University School of Medicine logo Indiana University School of Medicine
  • University of Washington Logo University of Washington

Lab Positions

Please reach out to Andrew Templin to learn about potential opportunities.