Mallone-You Lab

Research Focus

Exploring the mechanisms that fail to keep autoreactive T lymphocytes inoffensive and make beta cells more vulnerable to autoimmune attacks.

What We Do

Our research work focuses on type 1 diabetes (T1D), an autoimmune disease resulting from the destruction of insulin-producing pancreatic beta cells by the immune system, in particular by autoreactive T lymphocytes. We all harbor these autoreactive T lymphocytes but they are, in most cases, benign.

So why do they turn into a pathological and aggressive state in diabetic patients?

To answer this question, we are exploring the mechanisms that fail to keep autoreactive T lymphocytes inoffensive and make the beta cells more visible and vulnerable to an autoimmune attack.

This research will allow us to identify novel therapeutic targets to prevent and treat T1D.

Image of CD8+ T cells.

Staff Snapshot

Roberto Mallone, MD, PhD

Roberto Mallone, MD, PhD

Senior Investigator

  • Professor of Clinical Immunology and Hospital Physician in Diabetology, Paris Cité University, Cochin Hospital and INSERM U1016 Cochin Institute, 2019 to Present
  • Doctor of Philosophy, University of Turin, 2007
  • Medical Specialization in Internal Medicine, University of Turin, 2004
  • Postdoctoral Fellow, Benaroya Research Institute, 2004
  • Doctor of Medicine, University of Turin, 1999


Scientists interested in collaborating with the Mallone-You Lab on research should contact Roberto Mallone.

  • Indiana University School of Medicine logo Indiana University School of Medicine

Lab Positions

Please reach out to Roberto Mallone to learn about potential opportunities.