What We Do
Our research work focuses on type 1 diabetes (T1D), an autoimmune disease resulting from the destruction of insulin-producing pancreatic beta cells by the immune system, in particular by autoreactive T lymphocytes. We all harbor these autoreactive T lymphocytes but they are, in most cases, benign.
So why do they turn into a pathological and aggressive state in diabetic patients?
To answer this question, we are exploring the mechanisms that fail to keep autoreactive T lymphocytes inoffensive and make the beta cells more visible and vulnerable to an autoimmune attack.
This research will allow us to identify novel therapeutic targets to prevent and treat T1D.